Characterization of the 3a Protein of SARS-associated Coronavirus in Infected Vero E6 Cells and SARS Patients☆
Identifieur interne : 005426 ( Main/Exploration ); précédent : 005425; suivant : 005427Characterization of the 3a Protein of SARS-associated Coronavirus in Infected Vero E6 Cells and SARS Patients☆
Auteurs : Rong Zeng [République populaire de Chine] ; Rui-Fu Yang [République populaire de Chine] ; Mu-De Shi [République populaire de Chine] ; Man-Rong Jiang [République populaire de Chine] ; You-Hua Xie [République populaire de Chine] ; Hong-Qiang Ruan [République populaire de Chine] ; Xiao-Sheng Jiang [République populaire de Chine] ; Lv Shi [République populaire de Chine] ; Hu Zhou [République populaire de Chine] ; Lei Zhang [République populaire de Chine] ; Xiao-Dong Wu [République populaire de Chine] ; Ying Lin [République populaire de Chine] ; Yong-Yong Ji [République populaire de Chine] ; Lei Xiong [République populaire de Chine] ; Yan Jin [République populaire de Chine] ; Er-Hei Dai [République populaire de Chine] ; Xiao-Yi Wang [République populaire de Chine] ; Bin-Ying Si [République populaire de Chine] ; Jin Wang [République populaire de Chine] ; Hong-Xia Wang [République populaire de Chine] ; Cui-E Wang [République populaire de Chine] ; Yong-Hua Gan [République populaire de Chine] ; Yu-Chuan Li [République populaire de Chine] ; Ju-Tian Cao [République populaire de Chine] ; Jiang-Ping Zuo [République populaire de Chine] ; Shi-Fang Shan [République populaire de Chine] ; En Xie [République populaire de Chine] ; Song-Hua Chen [République populaire de Chine] ; Zhi-Qin Jiang [République populaire de Chine] ; Xi Zhang [République populaire de Chine] ; Yuan Wang [République populaire de Chine] ; Gang Pei [République populaire de Chine] ; Bing Sun [République populaire de Chine] ; Jia-Rui Wu [République populaire de Chine]Source :
- Journal of Molecular Biology [ 0022-2836 ] ; 2004.
Descripteurs français
- KwdFr :
- Analyse de séquence de protéine, Animaux, Cellules Vero, Disulfures (métabolisme), Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (métabolisme), Humains, Phylogénie, Protéines de l'enveloppe virale (métabolisme), Protéines virales (), Protéines virales (génétique), Protéines virales (métabolisme), Protéomique, Virus du SRAS (), Virus du SRAS (génétique), Virus du SRAS (métabolisme).
- MESH :
- génétique : Protéines virales, Virus du SRAS.
- métabolisme : Disulfures, Glycoprotéines membranaires, Protéines de l'enveloppe virale, Protéines virales, Virus du SRAS.
- Analyse de séquence de protéine, Animaux, Cellules Vero, Glycoprotéine de spicule des coronavirus, Humains, Phylogénie, Protéines virales, Protéomique, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Chlorocebus aethiops, Disulfides (metabolism), Humans, Membrane Glycoproteins (metabolism), Phylogeny, Proteomics, SARS Virus (chemistry), SARS Virus (genetics), SARS Virus (metabolism), Sequence Analysis, Protein, Spike Glycoprotein, Coronavirus, Vero Cells, Viral Envelope Proteins (metabolism), Viral Proteins (chemistry), Viral Proteins (genetics), Viral Proteins (metabolism).
- MESH :
- chemical , chemistry : Viral Proteins.
- chemical , genetics : Viral Proteins.
- chemical , metabolism : Disulfides, Membrane Glycoproteins, Viral Envelope Proteins, Viral Proteins.
- chemistry : SARS Virus.
- genetics : SARS Virus.
- metabolism : SARS Virus.
- Animals, Chlorocebus aethiops, Humans, Phylogeny, Proteomics, Sequence Analysis, Protein, Spike Glycoprotein, Coronavirus, Vero Cells.
Abstract
Proteomics was used to identify a protein encoded by ORF 3a in a SARS-associated coronavirus (SARS-CoV). Immuno-blotting revealed that interchain disulfide bonds might be formed between this protein and the spike protein. ELISA indicated that sera from SARS patients have significant positive reactions with synthesized peptides derived from the 3a protein. These results are concordant with that of a spike protein-derived peptide. A tendency exists for co-mutation between the 3a protein and the spike protein of SARS-CoV isolates, suggesting that the function of the 3a protein correlates with the spike protein. Taken together, the 3a protein might be tightly correlated to the spike protein in the SARS-CoV functions. The 3a protein may serve as a new clinical marker or drug target for SARS treatment.
Url:
DOI: 10.1016/j.jmb.2004.06.016
PubMed: 15312778
PubMed Central: 7127270
Affiliations:
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Le document en format XML
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type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Jin" sort="Wang, Jin" uniqKey="Wang J" first="Jin" last="Wang">Jin Wang</name><affiliation wicri:level="1"><nlm:aff id="AFF4">Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Hong Xia" sort="Wang, Hong Xia" uniqKey="Wang H" first="Hong-Xia" last="Wang">Hong-Xia Wang</name><affiliation wicri:level="1"><nlm:aff id="AFF4">Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of 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Beijing 100071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Li, Yu Chuan" sort="Li, Yu Chuan" uniqKey="Li Y" first="Yu-Chuan" last="Li">Yu-Chuan Li</name><affiliation wicri:level="1"><nlm:aff id="AFF4">Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Cao, Ju Tian" sort="Cao, Ju Tian" uniqKey="Cao J" first="Ju-Tian" last="Cao">Ju-Tian Cao</name><affiliation wicri:level="1"><nlm:aff id="AFF4">Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zuo, Jiang Ping" sort="Zuo, Jiang Ping" uniqKey="Zuo J" first="Jiang-Ping" last="Zuo">Jiang-Ping Zuo</name><affiliation wicri:level="1"><nlm:aff id="AFF5">State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu-Chong-Zhi Road, Shanghai 201203, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu-Chong-Zhi Road, Shanghai 201203</wicri:regionArea><wicri:noRegion>Shanghai 201203</wicri:noRegion></affiliation></author><author><name sortKey="Shan, Shi Fang" sort="Shan, Shi Fang" uniqKey="Shan S" first="Shi-Fang" last="Shan">Shi-Fang Shan</name><affiliation wicri:level="1"><nlm:aff id="AFF3">State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Xie, En" sort="Xie, En" uniqKey="Xie E" first="En" last="Xie">En Xie</name><affiliation wicri:level="1"><nlm:aff id="AFF6">Shanghai Laboratorial Animal Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Jiu-Tin Town, Shanghai 201615, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Laboratorial Animal Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Jiu-Tin Town, Shanghai 201615</wicri:regionArea><wicri:noRegion>Shanghai 201615</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Song Hua" sort="Chen, Song Hua" uniqKey="Chen S" first="Song-Hua" last="Chen">Song-Hua Chen</name><affiliation wicri:level="1"><nlm:aff id="AFF7">Cell Bank of Type Culture Collection Committee, Cell Resources Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cell Bank of Type Culture Collection Committee, Cell Resources Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Zhi Qin" sort="Jiang, Zhi Qin" uniqKey="Jiang Z" first="Zhi-Qin" last="Jiang">Zhi-Qin Jiang</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Xi" sort="Zhang, Xi" uniqKey="Zhang X" first="Xi" last="Zhang">Xi Zhang</name><affiliation wicri:level="1"><nlm:aff id="AFF8">Shanghai Center for Disease Control and Prevention, 1360 Zhong-Shang Road, Shanghai 200336, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Center for Disease Control and Prevention, 1360 Zhong-Shang Road, Shanghai 200336</wicri:regionArea><wicri:noRegion>Shanghai 200336</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yuan" sort="Wang, Yuan" uniqKey="Wang Y" first="Yuan" last="Wang">Yuan Wang</name><affiliation wicri:level="1"><nlm:aff id="AFF3">State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Pei, Gang" sort="Pei, Gang" uniqKey="Pei G" first="Gang" last="Pei">Gang Pei</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Bing" sort="Sun, Bing" uniqKey="Sun B" first="Bing" last="Sun">Bing Sun</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Jia Rui" sort="Wu, Jia Rui" uniqKey="Wu J" first="Jia-Rui" last="Wu">Jia-Rui Wu</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, 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type="wicri:Area/PubMed/Corpus">002C15</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002C15</idno><idno type="wicri:Area/PubMed/Curation">002C15</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002C15</idno><idno type="wicri:Area/PubMed/Checkpoint">002D92</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002D92</idno><idno type="wicri:Area/Ncbi/Merge">000A07</idno><idno type="wicri:Area/Ncbi/Curation">000A07</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A07</idno><idno type="wicri:doubleKey">0022-2836:2004:Zeng R:characterization:of:the</idno><idno type="wicri:Area/Main/Merge">005864</idno><idno type="wicri:Area/Main/Curation">005426</idno><idno type="wicri:Area/Main/Exploration">005426</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Characterization of the 3a Protein of SARS-associated Coronavirus in Infected Vero E6 Cells and SARS Patients<sup><xref ref-type="fn" rid="d32e787">☆</xref></sup></title><author><name sortKey="Zeng, Rong" sort="Zeng, Rong" uniqKey="Zeng R" first="Rong" last="Zeng">Rong Zeng</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Research Center for Proteome Analysis, Key Lab of Proteomics, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Center for Proteome Analysis, Key Lab of Proteomics, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Rui Fu" sort="Yang, Rui Fu" uniqKey="Yang R" first="Rui-Fu" last="Yang">Rui-Fu Yang</name><affiliation wicri:level="1"><nlm:aff id="AFF4">Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Shi, Mu De" sort="Shi, Mu De" uniqKey="Shi M" first="Mu-De" last="Shi">Mu-De Shi</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Man Rong" sort="Jiang, Man Rong" uniqKey="Jiang M" first="Man-Rong" last="Jiang">Man-Rong Jiang</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Xie, You Hua" sort="Xie, You Hua" uniqKey="Xie Y" first="You-Hua" last="Xie">You-Hua Xie</name><affiliation wicri:level="1"><nlm:aff id="AFF3">State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Ruan, Hong Qiang" sort="Ruan, Hong Qiang" uniqKey="Ruan H" first="Hong-Qiang" last="Ruan">Hong-Qiang Ruan</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Research Center for Proteome Analysis, Key Lab of Proteomics, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Center for Proteome Analysis, Key Lab of Proteomics, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Xiao Sheng" sort="Jiang, Xiao Sheng" uniqKey="Jiang X" first="Xiao-Sheng" last="Jiang">Xiao-Sheng Jiang</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Research Center for Proteome Analysis, Key Lab of Proteomics, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Center for Proteome Analysis, Key Lab of Proteomics, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Lv" sort="Shi, Lv" uniqKey="Shi L" first="Lv" last="Shi">Lv Shi</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Research Center for Proteome Analysis, Key Lab of Proteomics, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Center for Proteome Analysis, Key Lab of Proteomics, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Hu" sort="Zhou, Hu" uniqKey="Zhou H" first="Hu" last="Zhou">Hu Zhou</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Research Center for Proteome Analysis, Key Lab of Proteomics, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Center for Proteome Analysis, Key Lab of Proteomics, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Lei" sort="Zhang, Lei" uniqKey="Zhang L" first="Lei" last="Zhang">Lei Zhang</name><affiliation wicri:level="1"><nlm:aff id="AFF1">Research Center for Proteome Analysis, Key Lab of Proteomics, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Research Center for Proteome Analysis, Key Lab of Proteomics, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Xiao Dong" sort="Wu, Xiao Dong" uniqKey="Wu X" first="Xiao-Dong" last="Wu">Xiao-Dong Wu</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Ying" sort="Lin, Ying" uniqKey="Lin Y" first="Ying" last="Lin">Ying Lin</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Ji, Yong Yong" sort="Ji, Yong Yong" uniqKey="Ji Y" first="Yong-Yong" last="Ji">Yong-Yong Ji</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Xiong, Lei" sort="Xiong, Lei" uniqKey="Xiong L" first="Lei" last="Xiong">Lei Xiong</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Jin, Yan" sort="Jin, Yan" uniqKey="Jin Y" first="Yan" last="Jin">Yan Jin</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Dai, Er Hei" sort="Dai, Er Hei" uniqKey="Dai E" first="Er-Hei" last="Dai">Er-Hei Dai</name><affiliation wicri:level="1"><nlm:aff id="AFF4">Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Xiao Yi" sort="Wang, Xiao Yi" uniqKey="Wang X" first="Xiao-Yi" last="Wang">Xiao-Yi Wang</name><affiliation wicri:level="1"><nlm:aff id="AFF4">Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Si, Bin Ying" sort="Si, Bin Ying" uniqKey="Si B" first="Bin-Ying" last="Si">Bin-Ying Si</name><affiliation wicri:level="1"><nlm:aff id="AFF4">Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Jin" sort="Wang, Jin" uniqKey="Wang J" first="Jin" last="Wang">Jin Wang</name><affiliation wicri:level="1"><nlm:aff id="AFF4">Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Hong Xia" sort="Wang, Hong Xia" uniqKey="Wang H" first="Hong-Xia" last="Wang">Hong-Xia Wang</name><affiliation wicri:level="1"><nlm:aff id="AFF4">Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Cui E" sort="Wang, Cui E" uniqKey="Wang C" first="Cui-E" last="Wang">Cui-E Wang</name><affiliation wicri:level="1"><nlm:aff id="AFF4">Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Gan, Yong Hua" sort="Gan, Yong Hua" uniqKey="Gan Y" first="Yong-Hua" last="Gan">Yong-Hua Gan</name><affiliation wicri:level="1"><nlm:aff id="AFF4">Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Li, Yu Chuan" sort="Li, Yu Chuan" uniqKey="Li Y" first="Yu-Chuan" last="Li">Yu-Chuan Li</name><affiliation wicri:level="1"><nlm:aff id="AFF4">Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Cao, Ju Tian" sort="Cao, Ju Tian" uniqKey="Cao J" first="Ju-Tian" last="Cao">Ju-Tian Cao</name><affiliation wicri:level="1"><nlm:aff id="AFF4">Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zuo, Jiang Ping" sort="Zuo, Jiang Ping" uniqKey="Zuo J" first="Jiang-Ping" last="Zuo">Jiang-Ping Zuo</name><affiliation wicri:level="1"><nlm:aff id="AFF5">State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu-Chong-Zhi Road, Shanghai 201203, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu-Chong-Zhi Road, Shanghai 201203</wicri:regionArea><wicri:noRegion>Shanghai 201203</wicri:noRegion></affiliation></author><author><name sortKey="Shan, Shi Fang" sort="Shan, Shi Fang" uniqKey="Shan S" first="Shi-Fang" last="Shan">Shi-Fang Shan</name><affiliation wicri:level="1"><nlm:aff id="AFF3">State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Xie, En" sort="Xie, En" uniqKey="Xie E" first="En" last="Xie">En Xie</name><affiliation wicri:level="1"><nlm:aff id="AFF6">Shanghai Laboratorial Animal Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Jiu-Tin Town, Shanghai 201615, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Laboratorial Animal Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Jiu-Tin Town, Shanghai 201615</wicri:regionArea><wicri:noRegion>Shanghai 201615</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Song Hua" sort="Chen, Song Hua" uniqKey="Chen S" first="Song-Hua" last="Chen">Song-Hua Chen</name><affiliation wicri:level="1"><nlm:aff id="AFF7">Cell Bank of Type Culture Collection Committee, Cell Resources Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Cell Bank of Type Culture Collection Committee, Cell Resources Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Zhi Qin" sort="Jiang, Zhi Qin" uniqKey="Jiang Z" first="Zhi-Qin" last="Jiang">Zhi-Qin Jiang</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Xi" sort="Zhang, Xi" uniqKey="Zhang X" first="Xi" last="Zhang">Xi Zhang</name><affiliation wicri:level="1"><nlm:aff id="AFF8">Shanghai Center for Disease Control and Prevention, 1360 Zhong-Shang Road, Shanghai 200336, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Center for Disease Control and Prevention, 1360 Zhong-Shang Road, Shanghai 200336</wicri:regionArea><wicri:noRegion>Shanghai 200336</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yuan" sort="Wang, Yuan" uniqKey="Wang Y" first="Yuan" last="Wang">Yuan Wang</name><affiliation wicri:level="1"><nlm:aff id="AFF3">State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Pei, Gang" sort="Pei, Gang" uniqKey="Pei G" first="Gang" last="Pei">Gang Pei</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Bing" sort="Sun, Bing" uniqKey="Sun B" first="Bing" last="Sun">Bing Sun</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Jia Rui" sort="Wu, Jia Rui" uniqKey="Wu J" first="Jia-Rui" last="Wu">Jia-Rui Wu</name><affiliation wicri:level="1"><nlm:aff id="AFF2">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Molecular Biology</title><idno type="ISSN">0022-2836</idno><idno type="eISSN">1089-8638</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Disulfides (metabolism)</term><term>Humans</term><term>Membrane Glycoproteins (metabolism)</term><term>Phylogeny</term><term>Proteomics</term><term>SARS Virus (chemistry)</term><term>SARS Virus (genetics)</term><term>SARS Virus (metabolism)</term><term>Sequence Analysis, Protein</term><term>Spike Glycoprotein, Coronavirus</term><term>Vero Cells</term><term>Viral Envelope Proteins (metabolism)</term><term>Viral Proteins (chemistry)</term><term>Viral Proteins (genetics)</term><term>Viral Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de séquence de protéine</term><term>Animaux</term><term>Cellules Vero</term><term>Disulfures (métabolisme)</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires (métabolisme)</term><term>Humains</term><term>Phylogénie</term><term>Protéines de l'enveloppe virale (métabolisme)</term><term>Protéines virales ()</term><term>Protéines virales (génétique)</term><term>Protéines virales (métabolisme)</term><term>Protéomique</term><term>Virus du SRAS ()</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Disulfides</term><term>Membrane Glycoproteins</term><term>Viral Envelope Proteins</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines virales</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Disulfures</term><term>Glycoprotéines membranaires</term><term>Protéines de l'enveloppe virale</term><term>Protéines virales</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Humans</term><term>Phylogeny</term><term>Proteomics</term><term>Sequence Analysis, Protein</term><term>Spike Glycoprotein, Coronavirus</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence de protéine</term><term>Animaux</term><term>Cellules Vero</term><term>Glycoprotéine de spicule des coronavirus</term><term>Humains</term><term>Phylogénie</term><term>Protéines virales</term><term>Protéomique</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Proteomics was used to identify a protein encoded by ORF 3a in a SARS-associated coronavirus (SARS-CoV). Immuno-blotting revealed that interchain disulfide bonds might be formed between this protein and the spike protein. ELISA indicated that sera from SARS patients have significant positive reactions with synthesized peptides derived from the 3a protein. These results are concordant with that of a spike protein-derived peptide. A tendency exists for co-mutation between the 3a protein and the spike protein of SARS-CoV isolates, suggesting that the function of the 3a protein correlates with the spike protein. Taken together, the 3a protein might be tightly correlated to the spike protein in the SARS-CoV functions. The 3a protein may serve as a new clinical marker or drug target for SARS treatment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lai, M" uniqKey="Lai M">M. Lai</name></author><author><name sortKey="Holmes, K" uniqKey="Holmes K">K. 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